BRIP1 Antibody (PACO52750)
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주문- SKU:
- PACO52750
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BRIP1 Antibody (PACO52750) |
Antibody SKU: | PACO52750 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fanconi anemia group J protein (66-243AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO52750 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO52750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. |
Synonyms: | Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1), BRIP1, BACH1 FANCJ |
UniProt Protein Function: | BRIP1: a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Oncoprotein; Helicase; EC 3.6.4.13 Chromosomal Location of Human Ortholog: 17q22.2 Cellular Component: nuclear membrane; cytoplasm; nucleus Molecular Function:ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding Disease: Fanconi Anemia, Complementation Group J; Breast Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
NCBI Summary: | The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BX63 |
NCBI GenInfo Identifier: | 57012613 |
NCBI Gene ID: | 83990 |
NCBI Accession: | Q9BX63.1 |
UniProt Secondary Accession: | Q9BX63,Q3MJE2, Q8NCI5, |
UniProt Related Accession: | Q9BX63 |
Molecular Weight: | 1249 |
NCBI Full Name: | Fanconi anemia group J protein |
NCBI Synonym Full Names: | BRCA1 interacting protein C-terminal helicase 1 |
NCBI Official Symbol: | BRIP1 |
NCBI Official Synonym Symbols: | OF; BACH1; FANCJ |
NCBI Protein Information: | Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1/BRCA2-associated helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1 |
UniProt Protein Name: | Fanconi anemia group J protein |
UniProt Synonym Protein Names: | ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1 |
Protein Family: | Fanconi anemia group J protein |
UniProt Gene Name: | BRIP1 |
UniProt Entry Name: | FANCJ_HUMAN |
Antibodies |
Anti-BRIP1 Antibody (CAB6804) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |