BLK Antibody (PACO43442)
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주문- SKU:
- PACO43442
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BLK Antibody (PACO43442) |
Antibody SKU: | PACO43442 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43442 at dilution of 1:100. |
Background: | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. |
Synonyms: | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk), BLK |
UniProt Protein Function: | BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes |
UniProt Protein Details: | Protein type:Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family Chromosomal Location of Human Ortholog: 8p23-p22 Cellular Component: extrinsic to internal side of plasma membrane Molecular Function:protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding Biological Process: B cell receptor signaling pathway; innate immune response; positive regulation of insulin secretion; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation; T cell differentiation Disease: Maturity-onset Diabetes Of The Young, Type 11 |
NCBI Summary: | This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010] |
UniProt Code: | P51451 |
NCBI GenInfo Identifier: | 158936749 |
NCBI Gene ID: | 640 |
NCBI Accession: | P51451.3 |
UniProt Secondary Accession: | P51451,Q16291, Q96IN1, |
UniProt Related Accession: | P51451 |
Molecular Weight: | 505 |
NCBI Full Name: | Tyrosine-protein kinase Blk |
NCBI Synonym Full Names: | BLK proto-oncogene, Src family tyrosine kinase |
NCBI Official Symbol: | BLK |
NCBI Official Synonym Symbols: | MODY11 |
NCBI Protein Information: | tyrosine-protein kinase Blk; p55-Blk; b lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase |
UniProt Protein Name: | Tyrosine-protein kinase Blk |
UniProt Synonym Protein Names: | B lymphocyte kinase; p55-Blk |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | BLK |
UniProt Entry Name: | BLK_HUMAN |
Antibodies |
Anti-BLK Antibody (CAB7427) |
BLK Antibody (PACO00468) |
Phospho-BLK (Y501) Antibody (PACO05009) |
BLK Antibody (PACO08020) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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