BFAR Antibody (PACO18669)
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주문- SKU:
- PACO18669
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BFAR Antibody (PACO18669) |
Antibody SKU: | PACO18669 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human BFAR |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18669(BFAR Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. |
Synonyms: | bifunctional apoptosis regulator |
UniProt Protein Function: | BFAR: Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Apoptosis; Ubiquitin conjugating system; Membrane protein, integral Chromosomal Location of Human Ortholog: 16p13.12 Cellular Component: endoplasmic reticulum; membrane Molecular Function:protein binding; protein binding, bridging Biological Process: negative regulation of apoptosis; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
UniProt Code: | Q9NZS9 |
NCBI GenInfo Identifier: | 74753089 |
NCBI Gene ID: | 51283 |
NCBI Accession: | Q9NZS9.1 |
UniProt Secondary Accession: | Q9NZS9,A8K4Z9, B4DUT0, D3DUG8, |
UniProt Related Accession: | Q9NZS9 |
Molecular Weight: | 38,652 Da |
NCBI Full Name: | Bifunctional apoptosis regulator |
NCBI Synonym Full Names: | bifunctional apoptosis regulator |
NCBI Official Symbol: | BFAR |
NCBI Official Synonym Symbols: | BAR; RNF47 |
NCBI Protein Information: | bifunctional apoptosis regulator |
UniProt Protein Name: | Bifunctional apoptosis regulator |
UniProt Synonym Protein Names: | RING finger protein 47 |
Protein Family: | Bifunctional apoptosis regulator |
UniProt Gene Name: | BFAR |
UniProt Entry Name: | BFAR_HUMAN |
Antibodies |
Anti-BFAR Antibody (CAB8308) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |