BCLAF1 Antibody (PACO55334)
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주문- SKU:
- PACO55334
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BCLAF1 Antibody (PACO55334) |
Antibody SKU: | PACO55334 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Bcl-2-associated transcription factor 1 protein (218-407AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescent analysis of Hela cells using PACO55334 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
Synonyms: | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1), BCLAF1, BTF KIAA0164 |
UniProt Protein Function: | BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor; RNA-binding Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: nuclear speck; nucleolus; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding Biological Process: apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of transcription in response to stress |
NCBI Summary: | This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NYF8 |
NCBI GenInfo Identifier: | 47605556 |
NCBI Gene ID: | 9774 |
NCBI Accession: | Q9NYF8.2 |
UniProt Secondary Accession: | Q9NYF8,Q14673, Q86WU6, Q86WY0, A2RU75, B7ZM58, E1P586 |
UniProt Related Accession: | Q9NYF8 |
Molecular Weight: | 85,937 Da |
NCBI Full Name: | Bcl-2-associated transcription factor 1 |
NCBI Synonym Full Names: | BCL2 associated transcription factor 1 |
NCBI Official Symbol: | BCLAF1 |
NCBI Official Synonym Symbols: | BTF; bK211L9.1 |
NCBI Protein Information: | bcl-2-associated transcription factor 1 |
UniProt Protein Name: | Bcl-2-associated transcription factor 1 |
Protein Family: | Bcl-2-associated transcription factor |
UniProt Gene Name: | BCLAF1 |
UniProt Entry Name: | BCLF1_HUMAN |