UniProt Protein Function: | BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor; RNA-binding Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: nuclear speck; nucleolus; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding Biological Process: apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of transcription in response to stress |
NCBI Summary: | This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NYF8 |
NCBI GenInfo Identifier: | 47605556 |
NCBI Gene ID: | 9774 |
NCBI Accession: | Q9NYF8.2 |
UniProt Secondary Accession: | Q9NYF8,Q14673, Q86WU6, Q86WY0, A2RU75, B7ZM58, E1P586 |
UniProt Related Accession: | Q9NYF8 |
Molecular Weight: | 85,937 Da |
NCBI Full Name: | Bcl-2-associated transcription factor 1 |
NCBI Synonym Full Names: | BCL2 associated transcription factor 1 |
NCBI Official Symbol: | BCLAF1 |
NCBI Official Synonym Symbols: | BTF; bK211L9.1 |
NCBI Protein Information: | bcl-2-associated transcription factor 1 |
UniProt Protein Name: | Bcl-2-associated transcription factor 1 |
Protein Family: | Bcl-2-associated transcription factor |
UniProt Gene Name: | BCLAF1 |
UniProt Entry Name: | BCLF1_HUMAN |