BCL9 Antibody (PACO61506)
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주문- SKU:
- PACO61506
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BCL9 Antibody (PACO61506) |
Antibody SKU: | PACO61506 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human B-cell CLL/lymphoma 9 protein (231-340AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: BCL9 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 150 kDa. Observed band size: 150 kDa. |
![]() | IHC image of PACO61506 diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO61506 diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). |
Synonyms: | B-cell CLL/lymphoma 9 protein, B-cell lymphoma 9 protein, Bcl-9, Protein legless homolog, BCL9 |
UniProt Protein Function: | Bcl-9: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity. A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. Belongs to the BCL9 family.Protein type: Oncoprotein; Transcription factorChromosomal Location of Human Ortholog: 1q21Cellular Component: cis-Golgi network; nucleoplasmMolecular Function: protein bindingBiological Process: regulation of transforming growth factor beta receptor signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00512 |
NCBI GenInfo Identifier: | 206729930 |
NCBI Gene ID: | 607 |
NCBI Accession: | O00512.4 |
UniProt Secondary Accession: | O00512,Q5T489 |
UniProt Related Accession: | O00512 |
Molecular Weight: | 149,290 Da |
NCBI Full Name: | B-cell CLL/lymphoma 9 protein |
NCBI Synonym Full Names: | B-cell CLL/lymphoma 9 |
NCBI Official Symbol: | BCL9 |
NCBI Official Synonym Symbols: | LGS |
NCBI Protein Information: | B-cell CLL/lymphoma 9 protein |
UniProt Protein Name: | B-cell CLL/lymphoma 9 protein |
UniProt Synonym Protein Names: | Protein legless homolog |
Protein Family: | B-cell CLL/lymphoma 9 protein |
UniProt Gene Name: | BCL9 |
UniProt Entry Name: | BCL9_HUMAN |