BAG5 Antibody (PACO43484)
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주문- SKU:
- PACO43484
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BAG5 Antibody (PACO43484) |
Antibody SKU: | PACO43484 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human BAG family molecular chaperone regulator 5 protein (198-447AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: BAG5 antibody at 1µg/ml + A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 52, 57 kDa. Observed band size: 52 kDa. | |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO43484 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43484 at dilution of 1:100. |
Background: | Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. |
Synonyms: | BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5), BAG5, KIAA0873 |
UniProt Protein Function: | BAG5: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: membrane; mitochondrion; perinuclear region of cytoplasm; inclusion body; nucleus Molecular Function:protein binding; chaperone binding; ubiquitin protein ligase binding; protein kinase binding Biological Process: protein folding; negative regulation of ubiquitin-protein ligase activity; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UL15 |
NCBI GenInfo Identifier: | 12643895 |
NCBI Gene ID: | 9529 |
NCBI Accession: | Q9UL15.1 |
UniProt Secondary Accession: | Q9UL15,O94950, Q86W59, |
UniProt Related Accession: | Q9UL15 |
Molecular Weight: | 447 |
NCBI Full Name: | BAG family molecular chaperone regulator 5 |
NCBI Synonym Full Names: | BCL2-associated athanogene 5 |
NCBI Official Symbol: | BAG5 |
NCBI Official Synonym Symbols: | BAG-5 |
NCBI Protein Information: | BAG family molecular chaperone regulator 5; bcl-2-associated athanogene 5; BAG-family molecular chaperone regulator-5 |
UniProt Protein Name: | BAG family molecular chaperone regulator 5 |
UniProt Synonym Protein Names: | Bcl-2-associated athanogene 5 |
Protein Family: | BAG family molecular chaperone regulator |
UniProt Gene Name: | BAG5 |
UniProt Entry Name: | BAG5_HUMAN |