BAG2 Antibody (PACO43683)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43683
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BAG2 Antibody (PACO43683) |
Antibody SKU: | PACO43683 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human BAG family molecular chaperone regulator 2 protein (1-211AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: BAG family molecular chaperone regulator 2 antibody at 6µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24, 21 kDa. Observed band size: 24 kDa. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43683 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO43683 at dilution of 1:100. |
Background: | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. |
Synonyms: | BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2), BAG2 |
UniProt Protein Function: | BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 6p12.1-p11.2 Cellular Component: cytosol Molecular Function:adenyl-nucleotide exchange factor activity; identical protein binding; protein binding Biological Process: protein folding; protein metabolic process |
NCBI Summary: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95816 |
NCBI GenInfo Identifier: | 12229698 |
NCBI Gene ID: | 9532 |
NCBI Accession: | O95816.1 |
UniProt Secondary Accession: | O95816,Q08AS9, Q6FID0, B4DXE2, |
UniProt Related Accession: | O95816 |
Molecular Weight: | 20,189 Da |
NCBI Full Name: | BAG family molecular chaperone regulator 2 |
NCBI Synonym Full Names: | BCL2 associated athanogene 2 |
NCBI Official Symbol: | BAG2 |
NCBI Official Synonym Symbols: | BAG-2; dJ417I1.2 |
NCBI Protein Information: | BAG family molecular chaperone regulator 2 |
UniProt Protein Name: | BAG family molecular chaperone regulator 2 |
UniProt Synonym Protein Names: | Bcl-2-associated athanogene 2 |
Protein Family: | BAG family molecular chaperone regulator |
UniProt Gene Name: | BAG2 |
UniProt Entry Name: | BAG2_HUMAN |