ATPIF1 Antibody (PACO43930)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43930
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ATPIF1 Antibody (PACO43930) |
Antibody SKU: | PACO43930 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ATPase inhibitor, mitochondrial protein (26-106AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43930 at dilution of 1:100. |
Background: | Endogenous F1F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F1F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F1F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. |
Synonyms: | ATPase inhibitor, mitochondrial (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1), ATPIF1, ATPI |
UniProt Protein Function: | ATPIF1: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Inhibitor Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion Molecular Function:5-formyltetrahydrofolate cyclo-ligase activity; angiostatin binding; ATPase binding; ATPase inhibitor activity; calmodulin binding; enzyme inhibitor activity; protein homodimerization activity Biological Process: angiogenesis; erythrocyte differentiation; folic acid and derivative biosynthetic process; generation of precursor metabolites and energy; heme biosynthetic process; mitochondrial depolarization; negative regulation of ATPase activity; negative regulation of endothelial cell proliferation; negative regulation of hydrolase activity; protein homooligomerization; protein homotetramerization |
NCBI Summary: | This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UII2 |
NCBI GenInfo Identifier: | 12585262 |
NCBI Gene ID: | 93974 |
NCBI Accession: | Q9UII2.1 |
UniProt Secondary Accession: | Q9UII2,Q5JXL8, Q6IAQ7, Q9BSL9, |
UniProt Related Accession: | Q9UII2 |
Molecular Weight: | |
NCBI Full Name: | ATPase inhibitor, mitochondrial |
NCBI Synonym Full Names: | ATPase inhibitory factor 1 |
NCBI Official Symbol: | ATPIF1 |
NCBI Official Synonym Symbols: | IP; ATPI; ATPIP |
NCBI Protein Information: | ATPase inhibitor, mitochondrial |
UniProt Protein Name: | ATPase inhibitor, mitochondrial |
UniProt Synonym Protein Names: | Inhibitor of F(1)F(o)-ATPase; IF(1); IF1 |
Protein Family: | ATPase inhibitor |
UniProt Gene Name: | ATPIF1 |
UniProt Entry Name: | ATIF1_HUMAN |
Antibodies |
Anti-ATPIF1 Antibody (CAB5099) |
Anti-ATPIF1 Antibody (CAB19946)[KO Validated] |
ATPIF1 Antibody (PACO07948) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |