ATP6V0D1 Antibody (PACO45313)
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주문- SKU:
- PACO45313
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ATP6V0D1 Antibody (PACO45313) |
Antibody SKU: | PACO45313 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human V-type proton ATPase subunit d 1 protein (1-351AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO45313 at dilution of 1:100. |
Background: | Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acid, fying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). |
Synonyms: | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1), ATP6V0D1, ATP6D VPATPD |
UniProt Protein Function: | ATP6V0D1: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. Belongs to the V-ATPase V0D/AC39 subunit family. |
UniProt Protein Details: | Protein type:Hydrolase; Vesicle; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: centrosome; phagocytic vesicle membrane; synaptic vesicle; membrane; lysosomal membrane; apical plasma membrane; early endosome; endosome membrane; vacuolar proton-transporting V-type ATPase complex; nerve terminal Molecular Function:hydrogen-exporting ATPase activity, phosphorylative mechanism; protein binding; protein complex binding Biological Process: interaction with host; proton transport; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; cilium biogenesis; brain development; transmembrane transport |
NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61421 |
NCBI GenInfo Identifier: | 47606646 |
NCBI Gene ID: | 9114 |
NCBI Accession: | P61421.1 |
UniProt Secondary Accession: | P61421,P12953, Q02547, |
UniProt Related Accession: | P61421 |
Molecular Weight: | 351 |
NCBI Full Name: | V-type proton ATPase subunit d 1 |
NCBI Synonym Full Names: | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 |
NCBI Official Symbol: | ATP6V0D1 |
NCBI Official Synonym Symbols: | P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD |
NCBI Protein Information: | V-type proton ATPase subunit d 1; V-ATPase, subunit D; V-ATPase subunit d 1; V-ATPase AC39 subunit; 32 kDa accessory protein; vacuolar proton pump subunit d 1; V-ATPase 40 KDa accessory protein; H(+)-transporting two-sector ATPase, subunit D; ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D |
UniProt Protein Name: | V-type proton ATPase subunit d 1 |
UniProt Synonym Protein Names: | 32 kDa accessory protein; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; p39; Vacuolar proton pump subunit d 1 |
Protein Family: | V-type proton ATPase |
UniProt Gene Name: | ATP6V0D1 |
UniProt Entry Name: | VA0D1_HUMAN |