ATF7 Antibody (PACO43861)
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주문- SKU:
- PACO43861
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATF7 Antibody (PACO43861) |
Antibody SKU: | PACO43861 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO43861 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43861 at dilution of 1:100. |
Background: | Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. |
Synonyms: | Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A), ATF7, ATFA |
UniProt Protein Function: | Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. |
UniProt Code: | P17544 |
NCBI GenInfo Identifier: | 12643393 |
NCBI Gene ID: | 11016 |
NCBI Accession: | P17544.2 |
UniProt Secondary Accession: | P17544,Q13814, Q8IVR8, Q9UD83, A5D6Y4, B2RMP1, B4DQL4 |
UniProt Related Accession: | P17544 |
Molecular Weight: | 51,757 Da |
NCBI Full Name: | Cyclic AMP-dependent transcription factor ATF-7 |
NCBI Synonym Full Names: | activating transcription factor 7 |
NCBI Official Symbol: | ATF7 |
NCBI Official Synonym Symbols: | ATFA |
NCBI Protein Information: | cyclic AMP-dependent transcription factor ATF-7 |
UniProt Protein Name: | Cyclic AMP-dependent transcription factor ATF-7 |
UniProt Synonym Protein Names: | Activating transcription factor 7; Transcription factor ATF-A |
Protein Family: | Cyclic AMP-dependent transcription factor |
UniProt Gene Name: | ATF7 |
UniProt Entry Name: | ATF7_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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