ATF6B Antibody (PACO00438)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO00438
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATF6B Antibody |
Antibody SKU: | PACO00438 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human ATF-6Beta. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ATF6B; CREBL1; G13; Cyclic AMP-dependent transcription factor ATF-6 beta; cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein; |
UniProt Protein Function: | ATF6B: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to endoplasmic reticulum membrane; intracellular; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: signal transduction |
NCBI Summary: | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q99941 |
NCBI GenInfo Identifier: | 20137431 |
NCBI Gene ID: | 1388 |
NCBI Accession: | Q99941.2 |
UniProt Secondary Accession: | Q99941,Q13269, Q14343, Q14345, Q5SSW7, Q99635, Q99637 Q9H3V9, Q9H3W1, Q9NPL0, B0UYX6, |
UniProt Related Accession: | Q99941 |
Molecular Weight: | 76,412 Da |
NCBI Full Name: | Cyclic AMP-dependent transcription factor ATF-6 beta |
NCBI Synonym Full Names: | activating transcription factor 6 beta |
NCBI Official Symbol: | ATF6B |
NCBI Official Synonym Symbols: | G13; CREBL1; CREB-RP |
NCBI Protein Information: | cyclic AMP-dependent transcription factor ATF-6 beta |
UniProt Protein Name: | Cyclic AMP-dependent transcription factor ATF-6 beta |
UniProt Synonym Protein Names: | Activating transcription factor 6 beta; ATF6-beta |
Protein Family: | Cyclic AMP-dependent transcription factor |
UniProt Gene Name: | ATF6B |
UniProt Entry Name: | ATF6B_HUMAN |