ASPA Antibody (PACO15794)
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주문- SKU:
- PACO15794
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASPA Antibody (PACO15794) |
Antibody SKU: | PACO15794 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ASPA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15794(ASPA Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO15794(ASPA Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15794(ASPA Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid, (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. |
Synonyms: | aspartoacylase |
UniProt Protein Function: | ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - histidine; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 3.5.1.15; Hydrolase Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; metal ion binding; hydrolase activity, acting on ester bonds; aspartoacylase activity; aminoacylase activity Biological Process: myelination in the central nervous system; aspartate catabolic process; positive regulation of oligodendrocyte differentiation Disease: Canavan Disease |
NCBI Summary: | This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P45381 |
NCBI GenInfo Identifier: | 1168340 |
NCBI Gene ID: | 443 |
NCBI Accession: | P45381.1 |
UniProt Related Accession: | P45381 |
Molecular Weight: | 313 |
NCBI Full Name: | Aspartoacylase |
NCBI Synonym Full Names: | aspartoacylase |
NCBI Official Symbol: | ASPA |
NCBI Official Synonym Symbols: | ASP; ACY2 |
NCBI Protein Information: | aspartoacylase; ACY-2; aminoacylase 2; aminoacylase-2 |
UniProt Protein Name: | Aspartoacylase |
UniProt Synonym Protein Names: | Aminoacylase-2; ACY-2 |
Protein Family: | Aspartocin |
UniProt Gene Name: | ASPA |
UniProt Entry Name: | ACY2_HUMAN |
Antibodies | ELISA Kits |
Anti-ASPA Antibody (CAB7271) | Human Aspartoacylase (ASPA) ELISA Kit |
ASPA Antibody (PACO07888) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |