ASIP Antibody (PACO45678)
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주문- SKU:
- PACO45678
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASIP Antibody (PACO45678) |
Antibody SKU: | PACO45678 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Agouti-signaling protein (23-112AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO45678 at dilution of 1:100. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO45678 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
Synonyms: | Agouti-signaling protein (ASP) (Agouti switch protein), ASIP, AGTI AGTIL ASP |
UniProt Protein Function: | ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q11.2-q12 Cellular Component: extracellular space Molecular Function:type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; receptor binding Biological Process: melanin biosynthetic process; generation of precursor metabolites and energy; regulation of molecular function, epigenetic; hormone-mediated signaling; cell-cell signaling; melanosome organization and biogenesis; adult feeding behavior; signal transduction; melanosome transport Disease: Skin/hair/eye Pigmentation, Variation In, 9 |
NCBI Summary: | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42127 |
NCBI GenInfo Identifier: | 1168389 |
NCBI Gene ID: | 434 |
NCBI Accession: | P42127.1 |
UniProt Secondary Accession: | P42127,Q3SXL2, |
UniProt Related Accession: | P42127 |
Molecular Weight: | 132 |
NCBI Full Name: | Agouti-signaling protein |
NCBI Synonym Full Names: | agouti signaling protein |
NCBI Official Symbol: | ASIP |
NCBI Official Synonym Symbols: | ASP; AGSW; AGTI; AGTIL; SHEP9 |
NCBI Protein Information: | agouti-signaling protein; nonagouti homolog; agouti switch protein; agouti signaling protein, nonagouti homolog |
UniProt Protein Name: | Agouti-signaling protein |
UniProt Synonym Protein Names: | Agouti switch protein |
Protein Family: | Agouti-signaling protein |
UniProt Gene Name: | ASIP |
UniProt Entry Name: | ASIP_HUMAN |
Antibodies | ELISA Kits |
Anti-ASIP Antibody (CAB13280) | Human ASIP (Agouti-signaling protein) ELISA Kit (HUFI05460) |
Anti-ASIP Antibody (CAB6872) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |