ARL2 Antibody (PACO27881)
- SKU:
- PACO27881
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ARL2 Antibody (PACO27881) |
Antibody SKU: | PACO27881 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ADP-ribosylation factor-like protein 2 protein (19-184AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: ARL2 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 21, 19 kDa Observed band size: 21 kDa . |
Background: | The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. The Arf family is divided functionally into the Arf and the Arf-like (Arl) proteins. Arfs share more than 60% sequence identity, appear to be ubiquitous in eukaryotes, and are highly conserved evolutionarily. |
Synonyms: | ADP-ribosylation factor-like protein 2, ARL2 |
UniProt Protein Function: | ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family. |
UniProt Protein Details: | Protein type:G protein, monomeric, ARF; Mitochondrial; G protein, monomeric Chromosomal Location of Human Ortholog: 11q13 Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity Biological Process: tubulin folding; centrosome organization and biogenesis; metabolic process; small GTPase mediated signal transduction; positive regulation of microtubule polymerization; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization |
NCBI Summary: | This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008] |
UniProt Code: | P36404 |
NCBI GenInfo Identifier: | 116241255 |
NCBI Gene ID: | 402 |
NCBI Accession: | P36404.4 |
UniProt Related Accession: | P36404 |
Molecular Weight: | |
NCBI Full Name: | ADP-ribosylation factor-like protein 2 |
NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 2 |
NCBI Official Symbol: | ARL2 |
NCBI Official Synonym Symbols: | ARFL2 |
NCBI Protein Information: | ADP-ribosylation factor-like protein 2 |
UniProt Protein Name: | ADP-ribosylation factor-like protein 2 |
Protein Family: | ADP-ribosylation factor-like protein |
UniProt Gene Name: | ARL2 |
UniProt Entry Name: | ARL2_HUMAN |