ARHGEF3 Antibody (PACO45533)
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주문- SKU:
- PACO45533
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ARHGEF3 Antibody (PACO45533) |
Antibody SKU: | PACO45533 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Rho guanine nucleotide exchange factor 3 protein (287-526AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: ARHGEF3 antibody at 2.21µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: HepG2 whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: Hela whole cell lysate. Lane 5: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60, 64, 61, 37 kDa. Observed band size: 60 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45533 at dilution of 1:100. |
Background: | Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. |
Synonyms: | Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN), ARHGEF3 |
UniProt Protein Function: | ARHGEF3: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GAPs, Rac/Rho; GAPs Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: cytosol; intracellular Molecular Function:protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction |
NCBI Summary: | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NR81 |
NCBI GenInfo Identifier: | 52782760 |
NCBI Gene ID: | 50650 |
NCBI Accession: | Q9NR81.1 |
UniProt Secondary Accession: | Q9NR81,Q4FZB6, Q4QQI5, Q4QQQ0, Q59F00, Q6NUN3, Q7Z4U2 Q7Z5T2, Q9H7T4, A8K5U7, |
UniProt Related Accession: | Q9NR81 |
Molecular Weight: | 36,981 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 3 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 3 |
NCBI Official Symbol: | ARHGEF3 |
NCBI Official Synonym Symbols: | GEF3; STA3; XPLN |
NCBI Protein Information: | rho guanine nucleotide exchange factor 3 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 3 |
UniProt Synonym Protein Names: | Exchange factor found in platelets and leukemic and neuronal tissues; XPLN |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF3 |
UniProt Entry Name: | ARHG3_HUMAN |