APLN Antibody (PACO24977)
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주문- SKU:
- PACO24977
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | APLN Antibody (PACO24977) |
Antibody SKU: | PACO24977 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence from Human Apelin protein |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO24977 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO24977 at dilution of 1:100. |
Background: | Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. |
Synonyms: | Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13], APLN, APEL |
UniProt Protein Function: | apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq25 Cellular Component: extracellular space; extracellular region Molecular Function:G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding Biological Process: lactation; immune response; signal transduction |
NCBI Summary: | This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010] |
UniProt Code: | Q9ULZ1 |
NCBI GenInfo Identifier: | 20137569 |
NCBI Gene ID: | 8862 |
NCBI Accession: | Q9ULZ1.1 |
UniProt Secondary Accession: | Q9ULZ1,Q4VY08, Q8WU89, |
UniProt Related Accession: | Q9ULZ1 |
Molecular Weight: | 8,569 Da |
NCBI Full Name: | Apelin |
NCBI Synonym Full Names: | apelin |
NCBI Official Symbol: | APLN |
NCBI Official Synonym Symbols: | APEL; XNPEP2 |
NCBI Protein Information: | apelin; AGTRL1 ligand; APJ endogenous ligand |
UniProt Protein Name: | Apelin |
UniProt Synonym Protein Names: | APJ endogenous ligand |
UniProt Gene Name: | APLN |
UniProt Entry Name: | APEL_HUMAN |
Antibodies | ELISA Kits |
Anti-APLN Antibody (CAB18168) | Human Apelin ELISA Kit |
APLN Antibody (PACO01877) | Human APLN (Apelin) ELISA Kit (HUES01662) |
APLN Antibody (PACO07784) | Human Apelin (APLN) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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