Anti-WISP2 Antibody (CAB12541)
- SKU:
- CAB12541
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-WISP2 Antibody |
| Antibody SKU: | CAB12541 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human WISP2 (NP_003872.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human WISP2 (NP_003872.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VEVL GKCC PEWV CGQG GGLG TQPL PAQG PQFS GLVS SLPP GVPC PEWS TAWG PCST TCGL GMAT RVSN QNRF CRLE TQRR LCLS RPCP PSRG RSPQ NSAF |
| Gene ID: | 8839 |
| Uniprot: | O76076 |
| Cellular Location: | Secreted |
| Calculated MW: | 22kDa/26kDa |
| Observed MW: | Refer to figures |
| Synonyms: | WISP2, CCN5, CT58, CTGF-L |
| Background: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. |
| UniProt Protein Function: | WISP2: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Belongs to the CCN family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: extracellular space; proteinaceous extracellular matrix; plasma membrane Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding Biological Process: cell-cell signaling; regulation of cell growth; signal transduction; cell adhesion |
| NCBI Summary: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76076 |
| NCBI GenInfo Identifier: | 24211561 |
| NCBI Gene ID: | 8839 |
| NCBI Accession: | O76076.1 |
| UniProt Secondary Accession: | O76076,Q6PEG3, B2R9N4, E1P612, |
| UniProt Related Accession: | O76076 |
| Molecular Weight: | Observed: 27kDaCalculated: 22kDa/26kDa |
| NCBI Full Name: | WNT1-inducible-signaling pathway protein 2 |
| NCBI Synonym Full Names: | WNT1 inducible signaling pathway protein 2 |
| NCBI Official Symbol: | WISP2 |
| NCBI Official Synonym Symbols: | CCN5; CT58; CTGF-L |
| NCBI Protein Information: | WNT1-inducible-signaling pathway protein 2; WISP-2; CCN family member 5; wnt-1 signaling pathway protein 2; connective tissue growth factor-like protein; connective tissue growth factor-related protein 58 |
| UniProt Protein Name: | WNT1-inducible-signaling pathway protein 2 |
| UniProt Synonym Protein Names: | CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; Connective tissue growth factor-related protein 58 |
| Protein Family: | WNT1-inducible-signaling pathway protein |
| UniProt Gene Name: | WISP2 |
| UniProt Entry Name: | WISP2_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat brain using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens). |
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