Anti-UPP1 Antibody (CAB13051)

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SKU:
CAB13051
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-UPP1 Antibody
Antibody SKU:CAB13051
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 89-173 of human UPP1 (NP_001274357.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:HT-29, A-431, A-549, 293T, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 89-173 of human UPP1 (NP_001274357.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SYTE KDKQ AYLE AAYA AGVR NIEM ESSV FAAM CSAC GLQA AVVC VTLL NRLE GDQI SSPR NVLS EYQQ RPQR LVSY FIKK KLSK A
Gene ID:7378
Uniprot:Q16831
Cellular Location:
Calculated MW:3kDa/33kDa
Observed MW:36kDa
Synonyms:UPP1, UDRPASE, UP, UPASE, UPP
Background:This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides.
UniProt Protein Function:UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; EC 2.4.2.3; Transferase

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: cytosol

Molecular Function:uridine phosphorylase activity

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage

NCBI Summary:The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
UniProt Code:Q16831
NCBI GenInfo Identifier:2494059
NCBI Gene ID:7378
NCBI Accession:Q16831.1
UniProt Secondary Accession:Q16831,Q15362, D3DVM4,
UniProt Related Accession:Q16831
Molecular Weight:3,694 Da
NCBI Full Name:Uridine phosphorylase 1
NCBI Synonym Full Names:uridine phosphorylase 1
NCBI Official Symbol:UPP1  
NCBI Official Synonym Symbols:UP; UPP; UPASE; UDRPASE  
NCBI Protein Information:uridine phosphorylase 1
UniProt Protein Name:Uridine phosphorylase 1
Protein Family:Uridine phosphorylase
UniProt Gene Name:UPP1  
UniProt Entry Name:UPP1_HUMAN
Anti-UPP1 Antibody (CAB13051)Western blot analysis of extracts of various cell lines, using UPP1 Antibody (CAB13051) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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