Anti-TRK fused gene (TFG) Antibody (CAB1534)

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SKU:
CAB1534
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HMSNP
SPG57
TF6
TRKT3
Frequently bought together:

Description

Product Name:TRK fused gene (TFG) Rabbit mAb
Product Code:CAB1534
Size:20uL, 50uL, 100uL
Synonyms:HMSNP, SPG57, TF6, TRKT3
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TRK fused gene (TFG) (TFG)
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse testis, Mouse brain
Immunogen:A synthesized peptide derived from human TRK fused gene (TFG) (TFG)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10342
Uniprot:Q92734
Calculated MW:55kDa
Observed MW:55kDa
UniProt Protein Function:TFG: Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
UniProt Protein Details:

Protein type:Oncoprotein; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: cytosol

Molecular Function:protein binding; signal transducer activity

Biological Process: COPII coating of Golgi vesicle; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Neuropathy, Hereditary Motor And Sensory, Okinawa Type; Spastic Paraplegia 57, Autosomal Recessive

NCBI Summary:There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
UniProt Code:Q92734
NCBI GenInfo Identifier:223634676
NCBI Gene ID:10342
NCBI Accession:Q92734.2
UniProt Secondary Accession:Q92734,Q15656, Q969I2, D3DN49, G5E9V1, K0J5S8, K0J6K2
UniProt Related Accession:Q92734
Molecular Weight:30,921 Da
NCBI Full Name:Protein TFG
NCBI Synonym Full Names:TRK-fused gene
NCBI Official Symbol:TFG  
NCBI Official Synonym Symbols:TF6; HMSNP; SPG57; TRKT3  
NCBI Protein Information:protein TFG
UniProt Protein Name:Protein TFG
UniProt Synonym Protein Names:TRK-fused gene protein
Protein Family:Protein
UniProt Gene Name:TFG  
UniProt Entry Name:TFG_HUMAN

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