Anti-TREM2 Antibody (CAB10482)
- SKU:
- CAB10482
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TREM2 Antibody |
| Antibody SKU: | CAB10482 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human TREM2 (NP_061838.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human TREM2 (NP_061838.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HNTT VFQG VAGQ SLQV SCPY DSMK HWGR RKAW CRQL GEKG PCQR VVST HNLW LLSF LRRW NGST AITD DTLG GTLT ITLR NLQP HDAG LYQC QSLH GSEA DTLR KVLV EVLA DPLD HRDA GDLW FPGE SESF EDAH VEHS IS |
| Gene ID: | 54209 |
| Uniprot: | Q9NZC2 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 24kDa/25kDa |
| Observed MW: | 30-50KDa/28KDa |
| Synonyms: | TREM2, TREM-2, Trem2a, Trem2b, Trem2c |
| Background: | This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:receptor activity Biological Process: humoral immune response; innate immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy |
| NCBI Summary: | This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q9NZC2 |
| NCBI GenInfo Identifier: | 50401689 |
| NCBI Gene ID: | 54209 |
| NCBI Accession: | Q9NZC2.1 |
| UniProt Secondary Accession: | Q9NZC2,Q8N5H8, Q8WYN6, |
| UniProt Related Accession: | Q9NZC2 |
| Molecular Weight: | 25kDa |
| NCBI Full Name: | Triggering receptor expressed on myeloid cells 2 |
| NCBI Synonym Full Names: | triggering receptor expressed on myeloid cells 2 |
| NCBI Official Symbol: | TREM2 |
| NCBI Official Synonym Symbols: | TREM-2; Trem2a; Trem2b; Trem2c |
| NCBI Protein Information: | triggering receptor expressed on myeloid cells 2 |
| UniProt Protein Name: | Triggering receptor expressed on myeloid cells 2 |
| UniProt Synonym Protein Names: | Triggering receptor expressed on monocytes 2 |
| Protein Family: | Triggering receptor expressed on myeloid cells |
| UniProt Gene Name: | TREM2 |
 | Western blot analysis of extracts of various cell lines, using TREM2 antibody (CAB10482) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using TREM2 Rabbit pAb (CAB10482) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-251MG cells using TREM2 antibody (CAB10482) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse lung cells using TREM2 antibody (CAB10482) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of Rat lung using TREM2 antibody (CAB10482) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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