Anti-TNFRSF6B Antibody (CAB0649)

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SKU:
CAB0649
Product type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-TNFRSF6B Antibody
Antibody SKU:CAB0649
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human TNFRSF6B (NP_003814.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human TNFRSF6B (NP_003814.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TYPW RDAE TGER LVCA QCPP GTFV QRPC RRDS PTTC GPCP PRHY TQFW NYLE RCRY CNVL CGER EEEA RACH ATHN RACR CRTG FFAH AGFC LEHA SCPP GAGV IAPG TPSQ NTQC QPCP PGTF SASS SSSE QCQP HRNC TALG LALN VPGS SSHD TLCT SCTG FPLS TRVP GAEE CERA VIDF VAFQ DISI KRLQ RLLQ ALEA PEGW GPTP RAGR AALQ LKLR RRLT ELLG AQDG ALLV RLLQ ALRV ARMP GLER SVRE RFLP VH
Gene ID:8771
Uniprot:O95407
Cellular Location:Secreted
Calculated MW:32kDa
Observed MW:33kDa
Synonyms:TNFRSF6B, DCR3, DJ583P15.1.1, M68, M68E, TR6
Background:This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.
UniProt Protein Function:TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function:protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis

NCBI Summary:This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
UniProt Code:O95407
NCBI GenInfo Identifier:14790170
NCBI Gene ID:8771
NCBI Accession:NP_116563.1
UniProt Related Accession:O95407
Molecular Weight:32,680 Da
NCBI Full Name:
NCBI Synonym Full Names:TNF receptor superfamily member 6b
NCBI Official Symbol:TNFRSF6B  
NCBI Official Synonym Symbols:M68; TR6; DCR3; M68E; DJ583P15.1.1  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 6B
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 6B
UniProt Synonym Protein Names:Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF6B  
UniProt Entry Name:TNF6B_HUMAN
Anti-TNFRSF6B Antibody (CAB0649)Western blot analysis of extracts of HT-29 cells, using TNFRSF6B antibody (CAB0649) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
Anti-TNFRSF6B Antibody (CAB0649)Immunohistochemistry of paraffin-embedded human stomach using TNFRSF6B antibody (CAB0649) at dilution of 1:200 (40x lens).
Anti-TNFRSF6B Antibody (CAB0649)Immunohistochemistry of paraffin-embedded human kidney cancer using TNFRSF6B antibody (CAB0649) at dilution of 1:200 (40x lens).
Anti-TNFRSF6B Antibody (CAB0649)Immunohistochemistry of paraffin-embedded rat kidney using TNFRSF6B antibody (CAB0649) at dilution of 1:200 (40x lens).

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