Anti-TIMM10 Antibody (CAB4626)

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SKU:
CAB4626
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TIMM10
Synonyms:
TIM10
Synonyms:
TIM10A
Synonyms:
TIMM10A
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Description

Product Name:TIMM10 Rabbit pAb
Product Code:CAB4626
Size:20uL, 50uL, 100uL
Synonyms:TIMM10, TIM10, TIM10A, TIMM10A
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human TIMM10 (NP_036588.1).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, LO2, HepG2, NCI-H460, Mouse brain, Mouse small intestine, Mouse liver, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human TIMM10 (NP_036588.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDPL RAQQ LAAE LEVE MMAD MYNR MTSA CHRK CVPP HYKE AELS KGES VCLD RCVS KYLD IHER MGKK LTEL SMQD EELM KRVQ QSSG PA
Gene ID:26519
Uniprot:P62072
Cellular Location:Intermembrane side, Mitochondrion inner membrane, Peripheral membrane protein
Calculated MW:10kDa
Observed MW:12kDa
UniProt Protein Function:TIMM10: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Belongs to the small Tim family.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: mitochondrial intermembrane space protein transporter complex; mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial inner membrane presequence translocase complex

Molecular Function:protein binding; protein homodimerization activity; zinc ion binding; transporter activity; chaperone binding; protein transporter activity

Biological Process: cellular protein metabolic process; sensory perception of sound; protein import into mitochondrial inner membrane; protein targeting to mitochondrion

NCBI Summary:The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
UniProt Code:P62072
NCBI GenInfo Identifier:49065657
NCBI Gene ID:26519
NCBI Accession:P62072.1
UniProt Secondary Accession:P62072,Q9WV99, Q9WVA0, Q9Y5J8, A8K136,
UniProt Related Accession:P62072
Molecular Weight:90
NCBI Full Name:Mitochondrial import inner membrane translocase subunit Tim10
NCBI Synonym Full Names:translocase of inner mitochondrial membrane 10 homolog (yeast)
NCBI Official Symbol:TIMM10  
NCBI Official Synonym Symbols:TIM10; TIM10A  
NCBI Protein Information:mitochondrial import inner membrane translocase subunit Tim10
UniProt Protein Name:Mitochondrial import inner membrane translocase subunit Tim10
UniProt Gene Name:TIMM10  
UniProt Entry Name:TIM10_HUMAN
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