Anti-TIAM1 Antibody (CAB10252)
- SKU:
- CAB10252
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TIAM1 Antibody |
| Antibody SKU: | CAB10252 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SILR DKHR RQLL KTES LPSS QQYV PFGG KRLC ALKG ARPA MSRA VSAP SKSL GRRR RRLA RNRF TIDS DAVS ASSP EKES QQPP GGGD TDRW VEEQ FDLA QYEE QDDI KETD ILSD DDEF CESV KGAS VDRD LQER LQAT SISQ RERG RKTL DSHA SRMA QLKK QAAL SGIN GGLE SASE EVIW VRRE DFAP SRKL NTEI |
| Gene ID: | 7074 |
| Uniprot: | Q13009 |
| Cellular Location: | Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 170kDa/177kDa |
| Observed MW: | 250KDa |
| Synonyms: | TIAM1 |
| Background: |
| UniProt Protein Function: | TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes. |
| UniProt Protein Details: | Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction |
| UniProt Code: | Q13009 |
| NCBI GenInfo Identifier: | 152031709 |
| NCBI Gene ID: | 7074 |
| NCBI Accession: | Q13009.2 |
| UniProt Secondary Accession: | Q13009,Q17RT7, B7ZLR6, F5GZ53, |
| UniProt Related Accession: | Q13009 |
| Molecular Weight: | 178kDa |
| NCBI Full Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
| NCBI Synonym Full Names: | T-cell lymphoma invasion and metastasis 1 |
| NCBI Official Symbol: | TIAM1 |
| NCBI Protein Information: | T-lymphoma invasion and metastasis-inducing protein 1 |
| UniProt Protein Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
| Protein Family: | T-lymphoma invasion and metastasis-inducing protein |
| UniProt Gene Name: | TIAM1 |
 | Western blot analysis of extracts of Rat testis, using TIAM1 antibody (CAB10252) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00025). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using TIAM1 antibody (CAB10252) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using TIAM1 antibody (CAB10252) at dilution of 1:100 (40x lens). |
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