Anti-TAF6 Antibody (CAB16435)
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주문- SKU:
- CAB16435
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Antibody Name: | Anti-TAF6 Antibody |
Antibody SKU: | CAB16435 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Mouse |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TAF6 (XP_006716164.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Mouse |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TAF6 (XP_006716164.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | TKSW VDEK TPWT TRYG SIAG LAEL GHDV IKTL ILPR LQQE GERI RSVL DGPV LSNI DRIG ADHV QSLL LKHC APVL AKLR PPPD NQDA YRAE FGSL GPLL C |
Gene ID: | 6878 |
Uniprot: | P49848 |
Cellular Location: | Nucleus |
Calculated MW: | 71kDa/72kDa/76kDa |
Observed MW: | Refer to figures |
Synonyms: | TAF6, ALYUS, MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85 |
Background: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | TAF6: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Belongs to the TAF6 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor TFIID complex Molecular Function:DNA binding; protein binding; transcription factor activity Biological Process: negative regulation of cell cycle; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
UniProt Code: | P49848 |
NCBI GenInfo Identifier: | 1729810 |
NCBI Gene ID: | 6878 |
NCBI Accession: | P49848.1 |
UniProt Secondary Accession: | P49848,Q6AI29, A4D2B2, A4D2B3, B4DT11, D6W5U2, |
UniProt Related Accession: | P49848 |
Molecular Weight: | 76,995 Da |
NCBI Full Name: | Transcription initiation factor TFIID subunit 6 |
NCBI Synonym Full Names: | TATA-box binding protein associated factor 6 |
NCBI Official Symbol: | TAF6 |
NCBI Official Synonym Symbols: | TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80 |
NCBI Protein Information: | transcription initiation factor TFIID subunit 6 |
UniProt Protein Name: | Transcription initiation factor TFIID subunit 6 |
UniProt Synonym Protein Names: | RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80 |
Protein Family: | Transcription initiation factor |
UniProt Gene Name: | TAF6 |
UniProt Entry Name: | TAF6_HUMAN |
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