Anti-SPTBN1 Antibody (CAB5253)
- SKU:
- CAB5253
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SPTBN1 Antibody |
| Antibody SKU: | CAB5253 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, HeLa, Jurkat, LO2, 293T, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PPSP EPST KVSE EAES QQQW DTSK GEQV SQNG LPAE QGSP RMAE TVDT SEMV NGAT EQRT SSKE SSPI PSPT SDRK AKTA LPAQ SAAT LPAR TQET PSAQ M |
| Gene ID: | 6711 |
| Uniprot: | Q01082 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, M line, Peripheral membrane protein, cytoskeleton, myofibril, sarcomere |
| Calculated MW: | 251kDa/253kDa/274kDa |
| Observed MW: | 275kDa |
| Synonyms: | SPTBN1, ELF, HEL102, SPTB2, betaSpII, spectrin beta |
| Background: | Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| NCBI Summary: | Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q01082 |
| NCBI GenInfo Identifier: | 116242799 |
| NCBI Gene ID: | 6711 |
| NCBI Accession: | Q01082.2 |
| UniProt Secondary Accession: | Q01082,O60837, Q16057, Q53R99, Q59ER3, Q8IX99, B2RP63 |
| UniProt Related Accession: | Q01082 |
| Molecular Weight: | 251,397 Da |
| NCBI Full Name: | Spectrin beta chain, non-erythrocytic 1 |
| NCBI Synonym Full Names: | spectrin beta, non-erythrocytic 1 |
| NCBI Official Symbol: | SPTBN1 |
| NCBI Official Synonym Symbols: | ELF; SPTB2; HEL102; betaSpII |
| NCBI Protein Information: | spectrin beta chain, non-erythrocytic 1 |
| UniProt Protein Name: | Spectrin beta chain, non-erythrocytic 1 |
| UniProt Synonym Protein Names: | Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1 |
| Protein Family: | Spectrin |
| UniProt Gene Name: | SPTBN1 |
| UniProt Entry Name: | SPTB2_HUMAN |
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