Anti-SNRPN Antibody (CAB15726)
- SKU:
- CAB15726
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SNRPN Antibody |
| Antibody SKU: | CAB15726 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPN (NP_003088.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HT-29, HeLa, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPN (NP_003088.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTVG KSSK MLQH IDYR MRCI LQDG RIFI GTFK AFDK HMNL ILCD CDEF RKIK PKNA KQPE REEK RVLG LVLL RGEN LVSM TVEG PPPK DTGI ARVP LAGA |
| Gene ID: | 6638 |
| Uniprot: | P63162 |
| Cellular Location: | Nucleus |
| Calculated MW: | 24kDa/25kDa |
| Observed MW: | 20kDa |
| Synonyms: | SNRPN, HCERN3, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN, sm-N, PWS |
| Background: | The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. |
| UniProt Protein Function: | snRNP N: May be involved in tissue-specific alternative RNA processing events. Belongs to the snRNP SmB/SmN family. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 15q11.2 Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; snRNP U2; snRNP U1 Molecular Function:protein binding; RNA binding Biological Process: RNA splicing; response to hormone stimulus Disease: Prader-willi Syndrome; Autism |
| NCBI Summary: | The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P63162 |
| NCBI GenInfo Identifier: | 52783794 |
| NCBI Gene ID: | 6638 |
| NCBI Accession: | P63162.1 |
| UniProt Secondary Accession: | P63162,P14648, P17135, Q0D2Q5, B3KVR1, |
| UniProt Related Accession: | P63162 |
| Molecular Weight: | 25,076 Da |
| NCBI Full Name: | Small nuclear ribonucleoprotein-associated protein N |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide N |
| NCBI Official Symbol: | SNRPN |
| NCBI Official Synonym Symbols: | SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN |
| NCBI Protein Information: | small nuclear ribonucleoprotein-associated protein N; SM protein N; sm protein D; tissue-specific splicing protein |
| UniProt Protein Name: | Small nuclear ribonucleoprotein-associated protein N |
| UniProt Synonym Protein Names: | Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein |
| Protein Family: | SNRPN upstream reading frame protein |
| UniProt Gene Name: | SNRPN |
| UniProt Entry Name: | RSMN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNRPN antibody (CAB15726) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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