Anti-PTPN4 Antibody (CAB4061)
- SKU:
- CAB4061
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PTPN4 Antibody |
| Antibody SKU: | CAB4061 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, K-562, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PTPN4 (NP_002821.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTSR FRLP AGRT YNVR ASEL ARDR QHTE VVCN ILLL DNTV QAFK VNKH DQGQ VLLD VVFK HLDL TEQD YFGL QLAD DSTD NPRW LDPN KPIR KQLK RGSP YSLN FRVK FFVS DPNK LQEE YTRY QYFL QIKQ DILT GRLP CPSN TAAL LASF AVQS ELGD YDQS ENLS GYLS DYSF IPNQ PQDF EKEI AKLH QQHI GLSP AEAE FNYL NTAR TLEL YGVE FHYA RDQS NNEI MIGV MSGG |
| Gene ID: | 5775 |
| Uniprot: | P29074 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 105kDa |
| Observed MW: | 115kDa |
| Synonyms: | PTPN4, MEG, PTPMEG, PTPMEG1 |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. |
| UniProt Protein Function: | PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. |
| UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; cytoskeletal protein binding; non-membrane spanning protein tyrosine phosphatase activity Biological Process: protein amino acid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29074 |
| NCBI GenInfo Identifier: | 131531 |
| NCBI Gene ID: | 5775 |
| NCBI Accession: | P29074.1 |
| UniProt Secondary Accession: | P29074,Q9UDA7, B2RBV8, |
| UniProt Related Accession: | P29074 |
| Molecular Weight: | 926 |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 4 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) |
| NCBI Official Symbol: | PTPN4 |
| NCBI Official Synonym Symbols: | MEG; PTPMEG; PTPMEG1 |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 4 |
| UniProt Synonym Protein Names: | Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN4 |
| UniProt Entry Name: | PTN4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTPN4 antibody (CAB4061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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