Anti-PTP4A3 Antibody (CAB2004)
- SKU:
- CAB2004
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PTP4A3 Antibody |
| Antibody SKU: | CAB2004 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_009010.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_009010.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARM NRPA PVEV SYKH MRFL ITHN PTNA TLST FIED LKKY GATT VVRV CEVT YDKT PLEK DGIT VVDW PFDD GAPP PGKV VEDW LSLV KAKF CEAP GSCV AVHC VAGL GRKR RGAI NSKQ LTYL EKYR PKQR LRFK DPHT HKTR CCVM |
| Gene ID: | 11156 |
| Uniprot: | O75365 |
| Cellular Location: | Cell membrane, Early endosome |
| Calculated MW: | 10kDa/16kDa/19kDa |
| Observed MW: | 15kDa |
| Synonyms: | PTP4A3, PRL-3, PRL-R, PRL3 |
| Background: | This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PTP4A3: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: early endosome; plasma membrane Molecular Function:prenylated protein tyrosine phosphatase activity Biological Process: endothelial cell migration |
| NCBI Summary: | This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O75365 |
| NCBI GenInfo Identifier: | 68566154 |
| NCBI Gene ID: | 11156 |
| NCBI Accession: | O75365.2 |
| UniProt Secondary Accession: | O75365,Q8IVN5, Q99849, Q9BTW5, |
| UniProt Related Accession: | O75365 |
| Molecular Weight: | 173 |
| NCBI Full Name: | Protein tyrosine phosphatase type IVA 3 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase type IVA, member 3 |
| NCBI Official Symbol: | PTP4A3 |
| NCBI Official Synonym Symbols: | PRL3; PRL-3; PRL-R |
| NCBI Protein Information: | protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3 |
| UniProt Protein Name: | Protein tyrosine phosphatase type IVA 3 |
| UniProt Synonym Protein Names: | PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3 |
| UniProt Gene Name: | PTP4A3 |
| UniProt Entry Name: | TP4A3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTP4A3 antibody (CAB2004) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PTP4A3 antibody (CAB2004) at dilution of 1:100 (40x lens). |
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