Anti-PTDSS1 Antibody (CAB13065)
- SKU:
- CAB13065
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PTDSS1 Antibody |
| Antibody SKU: | CAB13065 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PTDSS1 (NP_055569.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PTDSS1 (NP_055569.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASC VGSR TLSK DDVN YKMH FRMI NEQQ VEDI TIDF FYRP HTIT LLSF TIVS LMYF AFTR DDSV PEDN IW |
| Gene ID: | 9791 |
| Uniprot: | P48651 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 56kDa |
| Observed MW: | 55kDa |
| Synonyms: | PTDSS1, LMHD, PSS1, PSSA |
| Background: | The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PTDSS1: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. Belongs to the phosphatidyl serine synthase family. |
| UniProt Protein Details: | Protein type:EC 2.7.8.29; Membrane protein, integral; Mitochondrial; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 8q22 Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane Molecular Function:transferase activity Biological Process: phosphatidylserine biosynthetic process; phospholipid biosynthetic process Disease: Lenz-majewski Hyperostotic Dwarfism |
| NCBI Summary: | The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] |
| UniProt Code: | P48651 |
| NCBI GenInfo Identifier: | 1346881 |
| NCBI Gene ID: | 9791 |
| NCBI Accession: | P48651.1 |
| UniProt Secondary Accession: | P48651,Q9BUQ5, B4DE85, E5RFC5, |
| UniProt Related Accession: | P48651 |
| Molecular Weight: | 34,579 Da |
| NCBI Full Name: | Phosphatidylserine synthase 1 |
| NCBI Synonym Full Names: | phosphatidylserine synthase 1 |
| NCBI Official Symbol: | PTDSS1 |
| NCBI Official Synonym Symbols: | LMHD; PSS1; PSSA |
| NCBI Protein Information: | phosphatidylserine synthase 1 |
| UniProt Protein Name: | Phosphatidylserine synthase 1 |
| UniProt Synonym Protein Names: | Serine-exchange enzyme I |
| Protein Family: | Phosphatidylserine synthase |
| UniProt Gene Name: | PTDSS1 |
| UniProt Entry Name: | PTSS1_HUMAN |
 | Western blot analysis of extracts of Raji cells, using PTDSS1 antibody (CAB13065) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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