Anti-PRSS2 항체 (CAB7923)

Antibody Name:	Anti-PRSS2 Antibody
Antibody SKU:	CAB7923
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	Mouse spleen, Mouse skeletal muscle

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	IVGG YICE ENSV PYQV SLNS GYHF CGGS LISE QWVV SAGH CYKS RIQV RLGE HNIE VLEG NEQF INAA KIIR HPKY NSRT LDND ILLI KLSS PAVI NSRV SAIS LPTA PPAA GTES LISG WGNT LSSG ADYP DELQ CLDA PVLS QAEC EASY PGKI TNNM FCVG FLEG GKDS CQGD SGGP VVSN GELQ GIVS WGYG CAQK NRPG VYTK VYNY VDWI KDTI AANS
Gene ID:	5645
Uniprot:	P07478
Cellular Location:	Secreted, extracellular space
Calculated MW:	26kDa
Observed MW:	26kDa

Synonyms:

PRSS2, TRY2, TRY8, TRYP2, trypsin-2

Background:

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.
UniProt Protein Details:	Protein type:Cell adhesion; Secreted, signal peptide; Calcium-binding; Secreted; EC 3.4.21.4; Extracellular matrix; Protease Chromosomal Location of Human Ortholog: 7q34 Cellular Component: extracellular matrix; extracellular region; extracellular space Molecular Function:calcium ion binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: collagen catabolic process; digestion; extracellular matrix disassembly; positive regulation of cell adhesion; positive regulation of cell growth; proteolysis Disease: Pancreatitis, Hereditary
NCBI Summary:	This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
UniProt Code:	P07478
NCBI GenInfo Identifier:	136413
NCBI Gene ID:	5645
NCBI Accession:	P07478.1
UniProt Related Accession:	P07478
Molecular Weight:	26,488 Da
NCBI Full Name:	Trypsin-2
NCBI Synonym Full Names:	protease, serine 2
NCBI Official Symbol:	PRSS2
NCBI Official Synonym Symbols:	TRY2; TRY8; TRYP2
NCBI Protein Information:	trypsin-2
UniProt Protein Name:	Trypsin-2
UniProt Synonym Protein Names:	Anionic trypsinogen; Serine protease 2; Trypsin II
Protein Family:	Trypsin
UniProt Gene Name:	PRSS2
UniProt Entry Name:	TRY2_HUMAN

Western blot analysis of extracts of various cell lines, using PRSS2 antibody (CAB7923) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies	ELISA Kits
PRSS2 Antibody (PACO11509)	Human Trypsin 2 / PRSS2 ELISA Kit
	Human PRSS2 (Protease, Serine, 2) CLIA Kit (HUES00680)
	Human PRSS2 (Protease, Serine, 2) ELISA Kit (HUES02250)
	Human Trypsin-2 (PRSS2) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)