Anti-PRSS2 Antibody (CAB19275)
- SKU:
- CAB19275
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PRSS2
- TRY2
- TRY8
- TRYP2
- trypsin-2
Frequently bought together:
Description
| Product Name: | PRSS2 Rabbit mAb |
| Product Code: | CAB19275 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PRSS2, TRY2, TRY8, TRYP2, trypsin-2 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PRSS2. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse pancreas, Rat pancreas |
| Immunogen: | Recombinant protein of human PRSS2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5645 |
| Uniprot: | P07478 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 30kDa |
| Observed MW: | 30KDa |
| UniProt Protein Function: | trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Secreted, signal peptide; Calcium-binding; Secreted; EC 3.4.21.4; Extracellular matrix; Protease Chromosomal Location of Human Ortholog: 7q34 Cellular Component: extracellular matrix; extracellular region; extracellular space Molecular Function:calcium ion binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: collagen catabolic process; digestion; extracellular matrix disassembly; positive regulation of cell adhesion; positive regulation of cell growth; proteolysis Disease: Pancreatitis, Hereditary |
| NCBI Summary: | This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015] |
| UniProt Code: | P07478 |
| NCBI GenInfo Identifier: | 136413 |
| NCBI Gene ID: | 5645 |
| NCBI Accession: | P07478.1 |
| UniProt Related Accession: | P07478 |
| Molecular Weight: | 26,488 Da |
| NCBI Full Name: | Trypsin-2 |
| NCBI Synonym Full Names: | protease, serine 2 |
| NCBI Official Symbol: | PRSS2 |
| NCBI Official Synonym Symbols: | TRY2; TRY8; TRYP2 |
| NCBI Protein Information: | trypsin-2 |
| UniProt Protein Name: | Trypsin-2 |
| UniProt Synonym Protein Names: | Anionic trypsinogen; Serine protease 2; Trypsin II |
| Protein Family: | Trypsin |
| UniProt Gene Name: | PRSS2 |
| UniProt Entry Name: | TRY2_HUMAN |
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