Anti-PRSS12 Antibody (CAB14319)
- SKU:
- CAB14319
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PRSS12 Antibody |
| Antibody SKU: | CAB14319 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human PRSS12 (NP_003610.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human PRSS12 (NP_003610.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FDSV LNDS LHHS HRHS PPAG PHYP YYLP TQQR PPRT RPPP PLPR FPRP PRAL PAQR PHAL QAGH TPRP HPWG CPAG EPWV SVTD FGAP CLRW AEVP PFLE RSPP ASWA QLRG QRHN FCRS PDGA GRPW CFYG DARG KVDW GYCD CRHG SVRL RGGK NEFE GTVE VYAS GVWG TVCS SHWD DSDA SVIC HQLQ LGGK GIAK QTPF SGLG LIPI YWSN VRCR GDEE NILL CEKD IWQG GVCP QKMA AAVT CSFS HGPT FPII RLAG GSSV HEGR VELY HAGQ |
| Gene ID: | 8492 |
| Uniprot: | P56730 |
| Cellular Location: | Secreted |
| Calculated MW: | 97kDa |
| Observed MW: | 97kDa |
| Synonyms: | PRSS12, BSSP-3, BSSP3, MRT1 |
| Background: | This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). |
| UniProt Protein Function: | PRSS12: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:Vesicle; Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 4q28.1 Cellular Component: axon; plasma membrane Molecular Function:serine-type peptidase activity Biological Process: exocytosis Disease: Mental Retardation, Autosomal Recessive 1 |
| NCBI Summary: | This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010] |
| UniProt Code: | P56730 |
| NCBI GenInfo Identifier: | 259016287 |
| NCBI Gene ID: | 8492 |
| NCBI Accession: | P56730.2 |
| UniProt Secondary Accession: | P56730,Q9UP16, |
| UniProt Related Accession: | P56730 |
| Molecular Weight: | 97,067 Da |
| NCBI Full Name: | Neurotrypsin |
| NCBI Synonym Full Names: | protease, serine 12 |
| NCBI Official Symbol: | PRSS12 |
| NCBI Official Synonym Symbols: | MRT1; BSSP3; BSSP-3 |
| NCBI Protein Information: | neurotrypsin |
| UniProt Protein Name: | Neurotrypsin |
| UniProt Synonym Protein Names: | Leydin; Motopsin; Serine protease 12 |
| Protein Family: | Neurotrypsin |
| UniProt Gene Name: | PRSS12 |
| UniProt Entry Name: | NETR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRSS12 antibody (CAB14319) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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