Anti-PROS1 Antibody (CAB1595)

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SKU:
CAB1595
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
Frequently bought together:

Description

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Antibody Name:Anti-PROS1 Antibody
Antibody SKU:CAB1595
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 405-676 of human PROS1 (NP_000304.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, HeLa, 293T, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 405-676 of human PROS1 (NP_000304.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDIN KPGP LFKP ENGL LETK VYFA GFPR KVES ELIK PINP RLDG CIRS WNLM KQGA SGIK EIIQ EKQN KHCL VTVE KGSY YPGS GIAQ FHID YNNV SSAE GWHV NVTL NIRP STGT GVML ALVS GNNT VPFA VSLV DSTS EKSQ DILL SVEN TVIY RIQA LSLC SDQQ SHLE FRVN RNNL ELST PLKI ETIS HEDL QRQL AVLD KAMK AKVA TYLG GLPD VPFS ATPV NAFY NGCM EVNI NGVQ LDLD EAIS KHND IRAH SCPS VWKK TKNS
Gene ID:5627
Uniprot:P07225
Cellular Location:Secreted
Calculated MW:75kDa
Observed MW:75kDa
Synonyms:PROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
Background:This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
UniProt Protein Function:PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: Golgi membrane; extracellular space; endoplasmic reticulum membrane; Golgi lumen; plasma membrane; extracellular region

Molecular Function:endopeptidase inhibitor activity; calcium ion binding

Biological Process: platelet activation; fibrinolysis; platelet degranulation; cellular protein metabolic process; regulation of complement activation; innate immune response; proteolysis; blood coagulation; post-translational protein modification; leukocyte migration; peptidyl-glutamic acid carboxylation

Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Recessive; Thrombophilia Due To Protein S Deficiency, Autosomal Dominant

NCBI Summary:This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
UniProt Code:P07225
NCBI GenInfo Identifier:131086
NCBI Gene ID:5627
NCBI Accession:P07225.1
UniProt Secondary Accession:P07225,Q08761, P53813,
UniProt Related Accession:P07225
Molecular Weight:676
NCBI Full Name:Vitamin K-dependent protein S
NCBI Synonym Full Names:protein S (alpha)
NCBI Official Symbol:PROS1  
NCBI Official Synonym Symbols:PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6  
NCBI Protein Information:vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S
UniProt Protein Name:Vitamin K-dependent protein S
Protein Family:Protein
UniProt Gene Name:PROS1  
UniProt Entry Name:PROS_HUMAN
Anti-PROS1 Antibody (CAB1595)Western blot analysis of extracts of various cell lines, using PROS1 antibody (CAB1595) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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