Anti-PLA2G4C Antibody (CAB7753)
- SKU:
- CAB7753
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PLA2G4C Antibody |
| Antibody SKU: | CAB7753 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human PLA2G4C (NP_003697.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human PLA2G4C (NP_003697.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSS EVSI IPGL QKEE KAAV ERRR LHVL KALK KLRI EADE APVV AVLG SGGG LRAH IACL GVLS EMKE QGLL DAVT YLAG VSGS TWAI SSLY TNDG DMEA LEAD LKHR FTRQ EWDL AKSL QKTI QAAR SENY SLTD FWAY MVIS KQTR ELPE SHLS NMKK PVEE GTLP YPIF AAID NDLQ PSWQ EARA P |
| Gene ID: | 8605 |
| Uniprot: | Q9UP65 |
| Cellular Location: | Lipid-anchor, Membrane |
| Calculated MW: | 59kDa/60kDa/62kDa |
| Observed MW: | 80kDa |
| Synonyms: | PLA2G4C, CPLA2-gamma |
| Background: | This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PLA2G4C: a calcium-independent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. Highly expressed in heart and skeletal muscle. |
| UniProt Protein Details: | Protein type:Phospholipase; Lipid Metabolism - arachidonic acid; EC 3.1.1.4 Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; nuclear envelope; cell cortex; cytosol Molecular Function:calcium-independent phospholipase A2 activity; phospholipid binding Biological Process: glycerophospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; arachidonic acid metabolic process; parturition; inflammatory response |
| NCBI Summary: | This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] |
| UniProt Code: | Q9UP65 |
| NCBI GenInfo Identifier: | 226693357 |
| NCBI Gene ID: | 8605 |
| NCBI Accession: | NP_001152794.1 |
| UniProt Secondary Accession: | Q9UP65,O75457, Q6IBI8, Q9UG68, B2RB71, B4DI40, |
| UniProt Related Accession: | Q9UP65 |
| Molecular Weight: | 62,451 Da |
| NCBI Full Name: | cytosolic phospholipase A2 gamma isoform 2 |
| NCBI Synonym Full Names: | phospholipase A2, group IVC (cytosolic, calcium-independent) |
| NCBI Official Symbol: | PLA2G4C |
| NCBI Official Synonym Symbols: | CPLA2-gamma |
| NCBI Protein Information: | cytosolic phospholipase A2 gamma; phospholipase A2 group IVC |
| UniProt Protein Name: | Cytosolic phospholipase A2 gamma |
| UniProt Synonym Protein Names: | Phospholipase A2 group IVC |
| Protein Family: | Cytosolic phospholipase |
| UniProt Gene Name: | PLA2G4C |
| UniProt Entry Name: | PA24C_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using PLA2G4C antibody (CAB7753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human tonsil using PLA2G4C antibody (CAB7753) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using PLA2G4C antibody (CAB7753) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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