Anti-PGE receptor EP4 (PTGER4) Antibody (CAB20295)

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SKU:
CAB20295
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PTGER4
Synonyms:
EP4
Synonyms:
EP4R
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Description

Product Name:PGE receptor EP4 (PTGER4) Rabbit pAb
Product Code:CAB20295
Size:50uL, 100uL
Synonyms:PTGER4, EP4, EP4R
Applications:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PGE receptor EP4 (PGE receptor EP4 (PTGER4)).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Rat
Immunogen:Recombinant protein of human PGE receptor EP4 (PGE receptor EP4 (PTGER4)).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5734
Uniprot:P35408
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:53kDa
Observed MW:Refer to figures
UniProt Protein Function:PTGER4: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: plasma membrane

Molecular Function:prostaglandin E receptor activity; protein binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; immune response; JNK cascade; negative regulation of cytokine secretion; negative regulation of inflammatory response; negative regulation of integrin activation; positive regulation of cytokine secretion; positive regulation of inflammatory response; regulation of stress fiber formation; response to mechanical stimulus; T-helper cell differentiation

NCBI Summary:The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
UniProt Code:P35408
NCBI GenInfo Identifier:548476
NCBI Gene ID:5734
NCBI Accession:P35408.1
UniProt Secondary Accession:P35408,Q3MJ87,
UniProt Related Accession:P35408
Molecular Weight:53,119 Da
NCBI Full Name:Prostaglandin E2 receptor EP4 subtype
NCBI Synonym Full Names:prostaglandin E receptor 4
NCBI Official Symbol:PTGER4  
NCBI Official Synonym Symbols:EP4; EP4R  
NCBI Protein Information:prostaglandin E2 receptor EP4 subtype
UniProt Protein Name:Prostaglandin E2 receptor EP4 subtype
UniProt Synonym Protein Names:Prostanoid EP4 receptor
Protein Family:Prostaglandin E2 receptor
UniProt Gene Name:PTGER4  
UniProt Entry Name:PE2R4_HUMAN
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