Anti-PDGFRL Antibody (CAB9169)
- SKU:
- CAB9169
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PDGFRL Antibody |
| Antibody SKU: | CAB9169 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-205 of human PDGFRL (NP_006198.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NCI-H125, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-205 of human PDGFRL (NP_006198.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALED VTGQ HLPK NKRP KEPG ENRI KPTN KKVK PKIP KMKD RDSA NSAP KTQS IMMQ VLDK GRFQ KPAA TLSL LAGQ TVEL RCKG SRIG WSYP AYLD TFKD SRLS VKQN ERYG QLTL VNST SADT GEFS CWVQ LCSG YICR KDEA KTGS TYIF FTEK GELF VPSP SYFD VVYL NPDR QAVV PCRV TVLS AKV |
| Gene ID: | 5157 |
| Uniprot: | Q15198 |
| Cellular Location: | Secreted |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | PDGFRL, PDGRL, PRLTS |
| Background: | This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. |
| UniProt Protein Function: | PDGFRL: Defects in PDGFRL are associated with colorectal cancer (CRC). |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Receptor, misc. Chromosomal Location of Human Ortholog: 8p22-p21.3 Molecular Function:platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity Disease: Hepatocellular Carcinoma |
| NCBI Summary: | This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15198 |
| NCBI GenInfo Identifier: | 74762141 |
| NCBI Gene ID: | 5157 |
| NCBI Accession: | Q15198.1 |
| UniProt Secondary Accession: | Q15198,Q6FH04, A8K085, |
| UniProt Related Accession: | Q15198 |
| Molecular Weight: | 41,861 Da |
| NCBI Full Name: | Platelet-derived growth factor receptor-like protein |
| NCBI Synonym Full Names: | platelet derived growth factor receptor like |
| NCBI Official Symbol: | PDGFRL |
| NCBI Official Synonym Symbols: | PDGRL; PRLTS |
| NCBI Protein Information: | platelet-derived growth factor receptor-like protein |
| UniProt Protein Name: | Platelet-derived growth factor receptor-like protein |
| UniProt Synonym Protein Names: | PDGF receptor beta-like tumor suppressor |
| Protein Family: | Platelet-derived growth factor receptor-like protein |
| UniProt Gene Name: | PDGFRL |
| UniProt Entry Name: | PGFRL_HUMAN |
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