Anti-PACRG Antibody (CAB15956)

(No reviews yet) Write a Review
SKU:
CAB15956
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-PACRG Antibody
Antibody SKU:CAB15956
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-549, BxPC-3, Raji, Mouse testis, Mouse lung, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IIPI KNAL NLRN RQVI CVTL KVLQ HLVV SAEM VGKA LVPY YRQI LPVL NIFK NMNV NSGD GIDY SQQK RENI GDLI QETL EAFE RYGG ENAF INIK YVVP T
Gene ID:135138
Uniprot:Q96M98
Cellular Location:
Calculated MW:29kDa/33kDa
Observed MW:35kDa
Synonyms:PACRG, GLUP, HAK005771, PARK2CRG
Background:This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PACRG: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytosol; neuron projection; nucleus; vesicle

Molecular Function:actin binding; alpha-tubulin binding; beta-tubulin binding; chaperone binding; G-protein-coupled receptor binding; heat shock protein binding; Hsp70 protein binding; Hsp90 protein binding; ubiquitin protein ligase binding

Disease: Leprosy, Susceptibility To, 2

NCBI Summary:This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q96M98
NCBI GenInfo Identifier:77416872
NCBI Gene ID:135138
NCBI Accession:Q96M98.2
UniProt Secondary Accession:Q96M98,Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9, E1P5B5,
UniProt Related Accession:Q96M98
Molecular Weight:29,312 Da
NCBI Full Name:Parkin coregulated gene protein
NCBI Synonym Full Names:PARK2 coregulated
NCBI Official Symbol:PACRG  
NCBI Official Synonym Symbols:GLUP; PARK2CRG; HAK005771  
NCBI Protein Information:parkin coregulated gene protein
UniProt Protein Name:Parkin coregulated gene protein
UniProt Synonym Protein Names:Molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein
Protein Family:PACRG-like protein
UniProt Gene Name:PACRG  
UniProt Entry Name:PACRG_HUMAN
Anti-PACRG Antibody (CAB15956)Western blot analysis of extracts of various cell lines, using PACRG antibody (CAB15956) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

0 Reviews

View AllClose

Related Products