Anti-NCS1 Antibody (CAB0598)
- SKU:
- CAB0598
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NCS1
- FLUP
- FREQ
- neuronal calcium sensor 1
Frequently bought together:
Description
| Product Name: | NCS1 Rabbit mAb |
| Product Code: | CAB0598 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NCS1, FLUP, FREQ, neuronal calcium sensor 1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NCS1. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 5637, 293T, U-87MG, Neuro-2a, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human NCS1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23413 |
| Uniprot: | P62166 |
| Cellular Location: | Cell junction, Cell membrane, Cytoplasm, Golgi apparatus, Golgi stack membrane, Lipid-anchor, Membrane, Peripheral membrane protein, perinuclear region, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
| UniProt Protein Function: | FREQ: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 9q34 Cellular Component: cytoplasm; intracellular membrane-bound organelle; plasma membrane Molecular Function:calcium ion binding; protein binding; voltage-gated calcium channel activity |
| NCBI Summary: | This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62166 |
| NCBI GenInfo Identifier: | 49065666 |
| NCBI Gene ID: | 23413 |
| NCBI Accession: | P62166.2 |
| UniProt Secondary Accession: | P62166,P36610, Q9UK26, E9PAY3, |
| UniProt Related Accession: | P62166 |
| Molecular Weight: | 19,728 Da |
| NCBI Full Name: | Neuronal calcium sensor 1 |
| NCBI Synonym Full Names: | neuronal calcium sensor 1 |
| NCBI Official Symbol: | NCS1 |
| NCBI Official Synonym Symbols: | FLUP; FREQ |
| NCBI Protein Information: | neuronal calcium sensor 1 |
| UniProt Protein Name: | Neuronal calcium sensor 1 |
| UniProt Synonym Protein Names: | Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein |
| Protein Family: | Frequenin |
| UniProt Gene Name: | NCS1 |
| UniProt Entry Name: | NCS1_HUMAN |
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