Anti-NCF4/p40-phox Antibody (CAB0935)

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SKU:
CAB0935
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NCF4
Synonyms:
CGD3
Synonyms:
NCF
Synonyms:
P40PHOX
Synonyms:
SH3PXD4
Synonyms:
neutrophil cytosol factor 4
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Description

Product Name:NCF4/p40-phox Rabbit mAb
Product Code:CAB0935
Size:20uL, 50uL, 100uL
Synonyms:NCF4, CGD3, NCF, P40PHOX, SH3PXD4, neutrophil cytosol factor 4
Applications:WB, IHC, IP
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human NCF4/p40-phox.
Applications:WB, IHC, IP
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:THP-1, Mouse thymus
Immunogen:A synthesized peptide derived from human NCF4/p40-phox.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4689
Uniprot:Q15080
Cellular Location:Cytoplasm, Cytoplasmic side, Endosome membrane, Membrane, Peripheral membrane protein, cytosol
Calculated MW:39kDa
Observed MW:40KDa
UniProt Protein Function:p40phox: a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed.
UniProt Protein Details:

Protein type:Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytosol; endosome membrane; membrane; NADPH oxidase complex

Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding; protein dimerization activity; superoxide-generating NADPH oxidase activator activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; immune response; vascular endothelial growth factor receptor signaling pathway

Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Iii

NCBI Summary:The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q15080
NCBI GenInfo Identifier:108884815
NCBI Gene ID:4689
NCBI Accession:Q15080.2
UniProt Secondary Accession:Q15080,O60808, Q86U56, Q9BU98, Q9NP45, A8K4F9,
UniProt Related Accession:Q15080
Molecular Weight:39,017 Da
NCBI Full Name:Neutrophil cytosol factor 4
NCBI Synonym Full Names:neutrophil cytosolic factor 4
NCBI Official Symbol:NCF4  
NCBI Official Synonym Symbols:NCF; CGD3; P40PHOX; SH3PXD4  
NCBI Protein Information:neutrophil cytosol factor 4
UniProt Protein Name:Neutrophil cytosol factor 4
UniProt Synonym Protein Names:Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phox
Protein Family:Neutrophil cytosol factor
UniProt Gene Name:NCF4  
UniProt Entry Name:NCF4_HUMAN
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