Anti-NAXE Antibody (CAB15952)
- SKU:
- CAB15952
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NAXE Antibody |
| Antibody SKU: | CAB15952 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-170 of human NAXE (NP_658985.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, NIH/3T3, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-170 of human NAXE (NP_658985.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DSEV MAST VVKY LSQE EAQA VDQE LFNE YQFS VDQL MELA GLSC ATAI AKAY PPTS MSRS PPTV LVIC GPGN NGGD GLVC ARHL KLFG YEPT IYYP KRPN KPLF TALV TQCQ KMDI PFLG EMP |
| Gene ID: | 128240 |
| Uniprot: | Q8NCW5 |
| Cellular Location: | Mitochondrion, Secreted |
| Calculated MW: | 20kDa/31kDa |
| Observed MW: | 32kDa |
| Synonyms: | NAXE, AIBP, APOA1BP, PEBEL, YJEFN1 |
| Background: | The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. |
| UniProt Protein Function: | APOA1BP: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Belongs to the nnrE/AIBP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.1.99.6; Mitochondrial Chromosomal Location of Human Ortholog: 1q21 Cellular Component: nucleoplasm; extracellular space; mitochondrion; intracellular membrane-bound organelle; cytoplasm; extracellular region; cilium Molecular Function:protein binding; protein homodimerization activity; metal ion binding; nucleotide binding Biological Process: NADH metabolic process; NADP metabolic process; protein homotetramerization |
| NCBI Summary: | The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NCW5 |
| NCBI GenInfo Identifier: | 91984773 |
| NCBI Gene ID: | 128240 |
| NCBI Accession: | NP_658985.2 |
| UniProt Secondary Accession: | Q8NCW5,Q496C6, Q5T3I2, B4DGY3, |
| UniProt Related Accession: | Q8NCW5 |
| Molecular Weight: | 20,431 Da |
| NCBI Full Name: | NAD(P)H-hydrate epimerase |
| NCBI Synonym Full Names: | apolipoprotein A-I binding protein |
| NCBI Official Symbol: | APOA1BP |
| NCBI Official Synonym Symbols: | AIBP; YJEFN1 |
| NCBI Protein Information: | NAD(P)H-hydrate epimerase |
| UniProt Protein Name: | NAD(P)H-hydrate epimerase |
| UniProt Synonym Protein Names: | Apolipoprotein A-I-binding protein |
| UniProt Gene Name: | APOA1BP |
| UniProt Entry Name: | NNRE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NAXE antibody (CAB15952) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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