Anti-MCU Antibody (CAB16281)
- SKU:
- CAB16281
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MCU Antibody |
| Antibody SKU: | CAB16281 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MCU (NP_612366.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MCU (NP_612366.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA AGRS LLLL LSSR GGGG GGAG GCGA LTAG CFPG LGVS RHRQ QQHH RTVH QRIA SWQN LGAV YCST VVPS DDVT VVYQ NGLP VISV RLPS RRER CQFT LKPI SDSV GVFL RQLQ EEDR GIDR VAIY SPDG VRVA ASTG IDLL LLDD FKLV INDL TYHV RPPK RDLL SHEN AATL NDVK TLVQ QLYT TLCI EQHQ LNKE RELI ERLE DLKE QLAP LEKV RIEI SRKA EKRT TLVL WGGL AYMA TQFG ILAR LTWW EYSW DIME PVTY FITY GSAM AMYA YFVM TRQE YVYP EARD RQYL LFFH KGAK KSRF DLEK YNQL KDAI AQAE MDLK RLRD PLQV HLPL RQIG EKD |
| Gene ID: | 90550 |
| Uniprot: | Q8NE86 |
| Cellular Location: | |
| Calculated MW: | 35kDa/36kDa/39kDa |
| Observed MW: | 26KDa |
| Synonyms: | MCU, C10orf42, CCDC109A, HsMCU |
| Background: | This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MCU: Mitochondrial inner membrane calcium transporter that mediates calcium uptake into mitochondrion. Belongs to the MCU family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: integral to mitochondrial inner membrane; mitochondrial inner membrane; mitochondrion Molecular Function:calcium channel activity; identical protein binding; protein binding; uniporter activity Biological Process: calcium-mediated signaling; elevation of mitochondrial calcium ion concentration; glucose homeostasis; mitochondrial calcium ion transport; positive regulation of insulin secretion |
| NCBI Summary: | This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q8NE86 |
| NCBI GenInfo Identifier: | 398303803 |
| NCBI Gene ID: | 90550 |
| NCBI Accession: | NP_001257608.1 |
| UniProt Secondary Accession: | Q8NE86,Q96FL3, B2RDF3, B3KXV7, |
| UniProt Related Accession: | Q8NE86 |
| Molecular Weight: | 35,159 Da |
| NCBI Full Name: | calcium uniporter protein, mitochondrial isoform 2 |
| NCBI Synonym Full Names: | mitochondrial calcium uniporter |
| NCBI Official Symbol: | MCU |
| NCBI Official Synonym Symbols: | C10orf42; CCDC109A |
| NCBI Protein Information: | calcium uniporter protein, mitochondrial |
| UniProt Protein Name: | Calcium uniporter protein, mitochondrial |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 109A |
| Protein Family: | Calcium uniporter protein |
| UniProt Gene Name: | MCU |
| UniProt Entry Name: | MCU_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using MCU Rabbit pAb (CAB16281) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of L929 cells using MCU antibody (CAB16281) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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