Anti-LRRC7 Antibody (CAB13114)

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SKU:
CAB13114
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-LRRC7 Antibody
Antibody SKU:CAB13114
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 730-890 of human LRRC7 (NP_065845.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 730-890 of human LRRC7 (NP_065845.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FPQP LDSK PLLS QREA VPPG NIPQ RPDR LPMS DTFT DNWT DGSH YDNT GFVA EETT AENA NSNP LLSS KSRS TSSH GRRP LIRQ DRIV GVPL ELEQ STHR HTPE TEVP PSNP WQNW TRTP SPFE DRTA FPSK LETT PTTS PLPE RKEH IKES TEIP SPFS P
Gene ID:57554
Uniprot:Q96NW7
Cellular Location:Cell junction, Cytoplasm, postsynaptic cell membrane, postsynaptic density, synapse
Calculated MW:20kDa/167kDa/172kDa
Observed MW:172kDa
Synonyms:LRRC7, DENSIN
Background:
UniProt Protein Function:LRRC7: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. Belongs to the LAP (LRR and PDZ) protein family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; cell junction

Molecular Function:protein binding

UniProt Code:Q96NW7
NCBI GenInfo Identifier:16904383
NCBI Gene ID:57554
NCBI Accession:NP_065845.1
UniProt Secondary Accession:Q96NW7,Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2
UniProt Related Accession:Q96NW7
Molecular Weight:20,546 Da
NCBI Full Name:leucine-rich repeat-containing protein 7
NCBI Synonym Full Names:leucine rich repeat containing 7
NCBI Official Symbol:LRRC7  
NCBI Official Synonym Symbols:DENSIN  
NCBI Protein Information:leucine-rich repeat-containing protein 7; densin-180
UniProt Protein Name:Leucine-rich repeat-containing protein 7
UniProt Synonym Protein Names:Densin-180; Densin; Protein LAP1
Protein Family:Protein
UniProt Gene Name:LRRC7  
UniProt Entry Name:LRRC7_HUMAN
Anti-LRRC7 Antibody (CAB13114)Western blot analysis of extracts of various cell lines, using LRRC7 antibody (CAB13114) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-LRRC7 Antibody (CAB13114)Immunofluorescence analysis of C6 cells using LRRC7 antibody (CAB13114) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-LRRC7 Antibody (CAB13114)Immunofluorescence analysis of L929 cells using LRRC7 antibody (CAB13114) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-LRRC7 Antibody (CAB13114)Immunofluorescence analysis of U-2 OS cells using LRRC7 antibody (CAB13114) at dilution of 1:100. Blue: DAPI for nuclear staining.

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