Anti-LNPEP Antibody (CAB11959)

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SKU:
CAB11959
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-LNPEP Antibody
Antibody SKU:CAB11959
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_005566.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HT-29, U-87MG, HeLa, Jurkat, Mouse brain, Mouse heart, Mouse liver, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_005566.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEPF TNDR LQLP RNMI ENSM FEEE PDVV DLAK EPCL HPLE PDEV EYEP RGSR LLVR GLGE HEME EDEE DYES SAKL LGMS FMNR SSGL RNSA TGYR QSPD GACS VPSA RT
Gene ID:4012
Uniprot:Q9UIQ6
Cellular Location:Cell membrane, Secreted, Single-pass type II membrane protein
Calculated MW:115kDa/117kDa
Observed MW:160kDa
Synonyms:LNPEP, CAP, IRAP, P-LAP, PLAP
Background:This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:IRAP: a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:EC 3.4.11.3; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: cytoplasmic vesicle membrane; cytosol; integral to plasma membrane; intracellular; lysosomal membrane; membrane; plasma membrane

Molecular Function:aminopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cell-cell signaling; female pregnancy; peptide catabolic process; protein polyubiquitination; regulation of blood pressure; signal transduction

NCBI Summary:This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UIQ6
NCBI GenInfo Identifier:145559489
NCBI Gene ID:4012
NCBI Accession:Q9UIQ6.3
UniProt Secondary Accession:Q9UIQ6,O00769, Q15145, Q59H76, Q9TNQ2, Q9TNQ3, Q9UIQ7
UniProt Related Accession:Q9UIQ6
Molecular Weight:117kDa
NCBI Full Name:Leucyl-cystinyl aminopeptidase
NCBI Synonym Full Names:leucyl and cystinyl aminopeptidase
NCBI Official Symbol:LNPEP  
NCBI Official Synonym Symbols:CAP; IRAP; PLAP; P-LAP  
NCBI Protein Information:leucyl-cystinyl aminopeptidase
UniProt Protein Name:Leucyl-cystinyl aminopeptidase
UniProt Synonym Protein Names:Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP
Protein Family:Leucyl-cystinyl aminopeptidase
UniProt Gene Name:LNPEP  
Anti-LNPEP Antibody (CAB11959)Western blot analysis of extracts of various cell lines, using LNPEP antibody (CAB11959) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-LNPEP Antibody (CAB11959)Immunohistochemistry of paraffin-embedded rat liver using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens).
Anti-LNPEP Antibody (CAB11959)Immunohistochemistry of paraffin-embedded rat brain using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens).
Anti-LNPEP Antibody (CAB11959)Immunohistochemistry of paraffin-embedded human placenta using LNPEP Rabbit pAb (CAB11959) at dilution of 1:100 (40x lens).

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