Anti-LIPH Antibody (CAB15215)
- SKU:
- CAB15215
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-LIPH Antibody |
| Antibody SKU: | CAB15215 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human LIPH (NP_640341.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, DU145, 293T, BxPC-3, A-549, Mouse testis, Mouse lung, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human LIPH (NP_640341.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KLRD KAGN TTES KINH EPTT FQKY HQVS LLAR FNQD LDKV AAIS LMFS TGSL IGPR YKLR ILRM KLRS LAHP ERPQ LCRY DLVL MENV ETVF QPIL CPEL Q |
| Gene ID: | 200879 |
| Uniprot: | Q8WWY8 |
| Cellular Location: | Membrane, Peripheral membrane protein, Secreted |
| Calculated MW: | 50kDa |
| Observed MW: | 54kDa |
| Synonyms: | LIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H |
| Background: | This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. |
| UniProt Protein Function: | LIPH: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7); also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. Belongs to the AB hydrolase superfamily. Lipase family. |
| UniProt Protein Details: | Protein type:Phospholipase; Secreted, signal peptide; Secreted; EC 3.1.1.- Chromosomal Location of Human Ortholog: 3q27 Cellular Component: extracellular space; plasma membrane Molecular Function:heparin binding; phospholipase activity Biological Process: lipid catabolic process Disease: Hypotrichosis 7 |
| NCBI Summary: | This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WWY8 |
| NCBI GenInfo Identifier: | 74762634 |
| NCBI Gene ID: | 200879 |
| NCBI Accession: | Q8WWY8.1 |
| UniProt Secondary Accession: | Q8WWY8,Q8TEC7, A2IBA7, |
| UniProt Related Accession: | Q8WWY8 |
| Molecular Weight: | 50,859 Da |
| NCBI Full Name: | Lipase member H |
| NCBI Synonym Full Names: | lipase, member H |
| NCBI Official Symbol: | LIPH |
| NCBI Official Synonym Symbols: | AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1 |
| NCBI Protein Information: | lipase member H; LPD lipase-related protein; lipase H; mPA-PLA1 alpha; membrane-associated phosphatidic acid-selective phospholipase A1-alpha; membrane-bound phosphatidic acid-selective phospholipase A1; phospholipase A1 member B |
| UniProt Protein Name: | Lipase member H |
| UniProt Synonym Protein Names: | LPD lipase-related protein; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; mPA-PLA1 alpha; Phospholipase A1 member B |
| Protein Family: | Lipase |
| UniProt Gene Name: | LIPH |
| UniProt Entry Name: | LIPH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LIPH antibody (CAB15215) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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