Anti-KRT3 Antibody (CAB10118)
- SKU:
- CAB10118
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-KRT3 Antibody |
Antibody SKU: | CAB10118 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-390 of human KRT3 (NP_476429.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | NCI-H460 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-390 of human KRT3 (NP_476429.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | WNLL QQQG TSSI SGTN NLEP LFEN HINY LRSY LDNI LGER GRLD SELK NMED LVED FKKK YEDE INKR TAAE NEFV TLKK DVDS AYMN KVEL QAKV DALI DEID FLRT LYDA ELSQ MQSH ISDT SVVL SMDN NRSL DLDS IIAE VRAQ YEDI AQRS KAEA E |
Gene ID: | 3850 |
Uniprot: | P12035 |
Cellular Location: | |
Calculated MW: | 64kDa |
Observed MW: | 65kDa |
Synonyms: | KRT3, CK3, K3, keratin 3 |
Background: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
UniProt Protein Function: | K3: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: keratin filament Molecular Function:structural molecule activity Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis Disease: Corneal Dystrophy, Meesmann |
NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
UniProt Code: | P12035 |
NCBI GenInfo Identifier: | 313104225 |
NCBI Gene ID: | 3850 |
NCBI Accession: | P12035.3 |
UniProt Secondary Accession: | P12035,Q701L8, A6NIS2, |
UniProt Related Accession: | P12035 |
Molecular Weight: | 64,417 Da |
NCBI Full Name: | Keratin, type II cytoskeletal 3 |
NCBI Synonym Full Names: | keratin 3 |
NCBI Official Symbol: | KRT3 |
NCBI Official Synonym Symbols: | K3; CK3 |
NCBI Protein Information: | keratin, type II cytoskeletal 3 |
UniProt Protein Name: | Keratin, type II cytoskeletal 3 |
UniProt Synonym Protein Names: | 65 kDa cytokeratin; Cytokeratin-3; CK-3; Keratin-3; K3; Type-II keratin Kb3 |
Protein Family: | Keratin |
UniProt Gene Name: | KRT3 |
UniProt Entry Name: | K2C3_HUMAN |