Anti-KLRC1 Antibody (CAB1233)
- SKU:
- CAB1233
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-KLRC1 Antibody |
| Antibody SKU: | CAB1233 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 96-215 of human KLRC1 (NP_015567.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse testis, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 96-215 of human KLRC1 (NP_015567.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RHCG HCPE EWIT YSNS CYYI GKER RTWE ESLL ACTS KNSS LLSI DNEE EMKF LSII SPSS WIGV FRNS SHHP WVTM NGLA FKHE IKDS DNAE LNCA VLQV NRLK SAQC GSSI IYHC KHKL |
| Gene ID: | 3821 |
| Uniprot: | P26715 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 24kDa/26kDa |
| Observed MW: | 26kDa |
| Synonyms: | KLRC1, CD159A, NKG2, NKG2A |
| Background: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| UniProt Protein Function: | Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P26715 |
| NCBI GenInfo Identifier: | 317373399 |
| NCBI Gene ID: | 3821 |
| NCBI Accession: | P26715.2 |
| UniProt Related Accession: | P26715 |
| Molecular Weight: | 24,250 Da |
| NCBI Full Name: | NKG2-A/NKG2-B type II integral membrane protein |
| NCBI Synonym Full Names: | killer cell lectin like receptor C1 |
| NCBI Official Symbol: | KLRC1 |
| NCBI Official Synonym Symbols: | NKG2; NKG2A; CD159A |
| NCBI Protein Information: | NKG2-A/NKG2-B type II integral membrane protein |
| UniProt Protein Name: | NKG2-A/NKG2-B type II integral membrane protein |
| UniProt Synonym Protein Names: | CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD_antigen: CD159a |
| UniProt Gene Name: | KLRC1 |
 | Western blot analysis of extracts of various cell lines, using KLRC1 antibody (CAB1233) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |