Anti-ITPKB 항체 (CAB3929)

Antibody Name:	Anti-ITPKB Antibody
Antibody SKU:	CAB3929
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ITPKB (NP_002212.3).

Application:	WB IHC
Recommended Dilution:	WB 1:200 - 1:2000 IHC 1:20 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, HepG2, BT-474, Mouse lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ITPKB (NP_002212.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MAVY CYAL NSLV IMNS ANEM KSGG GPGP SGSE TPPP PRRA VLSP GSVF SPGR GASF LFPP AESL SPEE PRSP GGWR SGRR RLNS SSGS GSGS SGSS VSSP SWAG RLRG DRQQ VVAA GTLS PPGP EEAK RKLR ILQR ELQN VQVN QKVG MFEA HIQA QSSA IQAP RSPR LGRA RSPS PCPF RSSS QPPG RVLV QGAR SEER RTKS WGEQ CPET SGTD SGRK GGPS LCSS QVKK GMPP LPGR AAPT GSEA QGPS AFVR MEKG
Gene ID:	3707
Uniprot:	P27987
Cellular Location:
Calculated MW:	67kDa/102kDa
Observed MW:	102kDa

Synonyms:

ITPKB, IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37

Background:

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

UniProt Protein Function:	ITPKB: The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
UniProt Protein Details:	Protein type:EC 2.7.1.127; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid Chromosomal Location of Human Ortholog: 1q42.13 Cellular Component: cytosol Molecular Function:calmodulin binding; protein binding; inositol trisphosphate 3-kinase activity; ATP binding Biological Process: cell surface receptor linked signal transduction; inositol phosphate metabolic process; MAPKKK cascade; positive regulation of Ras protein signal transduction; signal transduction; positive regulation of alpha-beta T cell differentiation; positive thymic T cell selection
NCBI Summary:	The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
UniProt Code:	P27987
NCBI GenInfo Identifier:	62906885
NCBI Gene ID:	3707
NCBI Accession:	P27987.5
UniProt Secondary Accession:	P27987,Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47,
UniProt Related Accession:	P27987
Molecular Weight:	946
NCBI Full Name:	Inositol-trisphosphate 3-kinase B
NCBI Synonym Full Names:	inositol-trisphosphate 3-kinase B
NCBI Official Symbol:	ITPKB
NCBI Official Synonym Symbols:	IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
NCBI Protein Information:	inositol-trisphosphate 3-kinase B; IP3K B; IP3 3-kinase B; insP 3-kinase B; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B
UniProt Protein Name:	Inositol-trisphosphate 3-kinase B
UniProt Synonym Protein Names:	Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B
Protein Family:	Inositol-trisphosphate 3-kinase
UniProt Gene Name:	ITPKB
UniProt Entry Name:	IP3KB_HUMAN

	Western blot analysis of extracts of various cell lines, using ITPKB antibody (CAB3929) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
	Immunohistochemistry of paraffin-embedded human liver damage using ITPKB antibody (CAB3929) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using ITPKB antibody (CAB3929) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded rat kidney using ITPKB antibody (CAB3929) at dilution of 1:100 (40x lens).

Antibodies

ITPKB Antibody (PACO05940)

ITPKB Antibody (PACO10019)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)