Anti-ITGB6 Antibody (CAB16904)
- SKU:
- CAB16904
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ITGB6 Antibody |
| Antibody SKU: | CAB16904 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 732-788 of human ITGB6 (NP_000879.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 732-788 of human ITGB6 (NP_000879.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLVS FHDR KEVA KFEA ERSK AKWQ TGTN PLYR GSTS TFKN VTYK HREK QKVD LSTD C |
| Gene ID: | 3694 |
| Uniprot: | P18564 |
| Cellular Location: | |
| Calculated MW: | 74kDa/85kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ITGB6, AI1H |
| Background: | This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). |
| NCBI Summary: | This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P18564 |
| NCBI GenInfo Identifier: | 9625002 |
| NCBI Gene ID: | 3694 |
| NCBI Accession: | NP_000879.2 |
| UniProt Secondary Accession: | P18564,Q0VA95, Q16500, Q53RG5, Q53RR6, B2R9W5, C9JA97 |
| UniProt Related Accession: | P18564 |
| Molecular Weight: | 86 |
| NCBI Full Name: | integrin beta-6 isoform a |
| NCBI Synonym Full Names: | integrin subunit beta 6 |
| NCBI Official Symbol: | ITGB6 |
| NCBI Official Synonym Symbols: | AI1H |
| NCBI Protein Information: | integrin beta-6 |
| UniProt Protein Name: | Integrin beta-6 |
| UniProt Gene Name: | ITGB6 |
 | Western blot analysis of extracts of various cell lines, using ITGB6 antibody (CAB16904) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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