Anti-IMPDH2 Antibody (CAB15626)
- SKU:
- CAB15626
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-IMPDH2 Antibody |
| Antibody SKU: | CAB15626 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DDEL VAII ARTD LKKN RDYP LASK DAKK QLLC GAAI GTHE DDKY RLDL LAQA GVDV VVLD SSQG NSIF QINM IKYI KDKY PNLQ VIGG NVVT AAQA KNLI DAGV DALR VGMG SGSI CITQ EVLA CGRP QATA VYKV SEYA RRFG VPVI ADGG IQNV GHIA KALA LGAS TVMM GSLL AATT EAPG EYFF SDGI RLKK YRGM GSLD AMDK HLSS QNRY FSEA DKIK VAQG VSGA VQDK GSIH KFVP YLIA GIQH SCQD IGAK SLTQ VRAM MYSG ELKF EKRT SSAQ VEGG VHSL HSYE KRLF |
| Gene ID: | 3615 |
| Uniprot: | P12268 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 55kDa |
| Observed MW: | 56kDa |
| Synonyms: | IMPDH2, IMPD2, IMPDH-II |
| Background: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
| UniProt Protein Function: | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| NCBI Summary: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12268 |
| NCBI GenInfo Identifier: | 124419 |
| NCBI Gene ID: | 3615 |
| NCBI Accession: | P12268.2 |
| UniProt Secondary Accession: | P12268,Q6LEF3, |
| UniProt Related Accession: | P12268 |
| Molecular Weight: | 55,805 Da |
| NCBI Full Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| NCBI Synonym Full Names: | inosine monophosphate dehydrogenase 2 |
| NCBI Official Symbol: | IMPDH2 |
| NCBI Official Synonym Symbols: | IMPD2; IMPDH-II |
| NCBI Protein Information: | inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Protein Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Synonym Protein Names: | IMPDH-II |
| UniProt Gene Name: | IMPDH2 |
 | Western blot analysis of extracts of various cell lines, using IMPDH2 antibody (CAB15626) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using IMPDH2 Rabbit pAb (CAB15626) at dilution of 1:100 (40x lens). |
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